High Dose Meclizine Prevents Renal Ischemia–Reperfusion Injury in Healthy Male Mice
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High Dose Meclizine Prevents Renal Ischemia–Reperfusion Injury in Healthy Male Mice
In this issue of EBioMedicine, Kishi et al. report on their intriguing finding that pre-treatment with meclizine prevents renal ischemia– reperfusion injury in male mice (Kishi et al. 2015). Furthermore, they provide a potential mode of action of this reno-protective intervention: intracellular accumulation of phosphoethanolamine, which in turn activates glycolysis and attenuates mitochondrial ...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2015
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2015.09.016